Abstract
The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.
MeSH terms
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Animals
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Dogs
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Drug Discovery*
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Humans
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Janus Kinase 2 / antagonists & inhibitors*
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Mice
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Molecular Structure
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Protein Kinase Inhibitors / chemical synthesis
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Pyrazines / chemical synthesis
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Pyrazines / chemistry
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Pyrazines / pharmacology*
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Rats
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Protein Kinase Inhibitors
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Pyrazines
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Pyrazoles
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Janus Kinase 2